Is it normal to feel sleepy on buprenorphine?
When you are on buprenorphine, you may have wondered about the relationship between buprenorphine and sleep. If you find yourself dealing with a constant feeling of sleepiness or are concerned that this medication may be affecting your quality of sleep, you are not alone. Many clients often ask their physician, “Is it normal to feel sleepy on buprenorphine?” Buprenorphine, which is commonly used by doctors in opioid addiction treatments, has a significant impact on the body and brain, which can lead to some unexpected side effects, such as drowsiness. Understanding why this happens is essential to getting the most out of your treatment without sacrificing your daily well-being.
It’s completely normal to feel sleepy on buprenorphine, but there’s more behind this side effect than just feeling tired. In this MAT Care Clinics blog, you can explore how buprenorphine affects sleep, how long this effect lasts, and what steps you can take to manage it.

Buprenorphine and Sleep: Understanding the Relationship
Buprenorphine is a partial agonist of opioid receptors in the brain, meaning that it activates these receptors but not in the same intense way that other opioids do. Although this action reduces withdrawal symptoms and cravings, it can also interfere with natural sleep-wake cycles.
One of the most common effects of buprenorphine is drowsiness or lethargy, which is related to its impact on the central nervous system. This drug can slow down the brain, causing a feeling of tiredness or sleepiness during the day. Studies about buprenorphine and sleep show that buprenorphine can change the pattern of sleep and wakefulness, causing individuals to spend more time awake and less time in light (NREM) and deep (REM) sleep phases.
These alterations mean that some patients may experience insomnia or fragmented sleep, as buprenorphine can disrupt the deep sleep cycle and REM phase, which are crucial for restful sleep. Disruption in this essential phase of sleep can result in feelings of exhaustion during the day despite having spent several hours in bed.
Buprenorphine Sleep Disturbances: What Are the Symptoms
When we talk about buprenorphine and sleep, we must understand that this medication has a depressant effect on the central nervous system. One of its effects is the stimulation of the production of GABA in the brain. The function of the neurotransmitter GABA is to slow down brain activity and promote relaxation. Therefore, buprenorphine sleep disturbances can cause additional symptoms such as:
- Fatigue

- Drowsiness
- Muscle weakness
- Low heart rate
- Slowed breathing
- Lower blood pressure
- Slow reactions
Sleep Problems During Buprenorphine Treatment: How Long Does it Last?
The length of time sleepiness persists with buprenorphine varies in each individual. In the first few weeks of treatment, the body is adjusting to the medication, which may intensify sleep disturbances. However, many people report that these side effects subside as their body gets used to the medication, usually after two to four weeks.
In fact, a study in the Journal of Drug Abuse and Addiction found that the use of buprenorphine in medication-assisted treatment (MAT) correlated with improved sleep during the first 90 days of treatment. However, other factors, such as therapy and peer support group sessions, may also contribute to this outcome.
However, if sleep problems during buprenorphine treatment go beyond four weeks, it is essential to contact your treating physician to make adjustments or consider strategies for managing fatigue. Everybody reacts differently to medication, so a personalized approach is vital.
Is Buprenorphine Safe?
Buprenorphine is safe and effective in the treatment of opioid addiction. Organizations such as the U.S. Food and Drug Administration (FDA) and the World Health Organization (WHO) have widely endorsed it. However, as with any medication, individuals and their medical providers must manage it has side effects appropriately.
The main risk associated with buprenorphine and sleep is the possibility of accidents or falls due to drowsiness. Suppose you experience a level of fatigue that interferes with your daily activities. In that case, it is crucial to adjust your routine to avoid dangerous situations, like driving or working with heavy machinery while under the effects of this medication.
Among the benefits of buprenorphine treatment, we can find:
- Reduced cravings: By acting as an opioid in the body, it decreases cravings and helps individuals focus on their recovery.
- Manages withdrawal symptoms: Withdrawal symptoms are one of the most common reasons why people relapse into addiction. Buprenorphine can help prevent withdrawal symptoms, improving the recovery experience.
- Reduces the risk of overdose: Withdrawal can lead a person to relapse into old habits. Buprenorphine addresses opioid receptors in the brain in a controlled manner, preventing the person from reaching a state of euphoria.
In terms of long-term use, studies indicate that buprenorphine has a favorable safety profile, especially compared to other opioids. However, individuals should always follow medical guidance to ensure safe and effective treatment.
Buprenorphine Sleep Disturbances: What Do Experts Recommend
Managing sleep problems during buprenorphine treatment requires a proactive approach. Here are some recommendations based on best practices:
- Monitor your sleep habits: Record how many hours you sleep, how you feel when you wake up, and whether you experience drowsiness during the day. This information can help your doctor to adjust your treatment if necessary.
- Adjust the dose: In some cases, your doctor may recommend slightly reducing the dose of buprenorphine to minimize side effects without compromising the benefits of treatment.
- Sleep hygiene: Create a regular sleep routine with consistent schedules and an environment conducive to rest (darkness, quiet, comfortable bed). Avoid screens, sugar, and caffeine close to bedtime.
- Consult a specialist: If sleep problems persist, consider consulting a sleep specialist or mental health professional who can offer stress management techniques or cognitive-behavioral therapy for insomnia.

Buprenorphine and Sleep: Access Professional Support with MAT Care Clinics
Buprenorphine is a powerful tool for addiction recovery, but like any treatment, it has side effects. Feeling sleepy during treatment is normal, especially in the first few weeks, but over time, most people find that these effects lessen, and their sleep improves. It is critical to work closely with your medical team to monitor how the medication is affecting you and adjust treatment if necessary.
While drowsiness is a common side effect, there are many ways to manage sleep problems during buprenorphine treatment so that you can continue your recovery safely and effectively. If you are concerned about how buprenorphine is affecting your sleep, don’t hesitate to speak with a specialist at MAT Care Clinics to find the best solution for you.
Call us at (833) 622-0628 or contact us online. We’re here for you 24/7!




